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KMID : 1123920170310030182
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Korean Journal of Oriental Physiology and Pathology
2017 Volume.31 No. 3 p.182 ~ p.187
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Investigation of the Antioxidant Effect of Angelicae Radix from K orea, China and Japan
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Cho Nam-Joon
Lee Woong-Hee
Kim Kee-Kwang
Han Hyo-Sang
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Abstract
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The purpose of the present study is a comparison of the antioxidant effects of Angelica gigas Korea (AG), Angelica sinensis of China (AS), and Angelica acutiloba of Japan (AA), and comparison of the effects of AG, AS and AA on tight-junction related genes in human keratinocyte HaCaT cells. All species showed a strong antioxidant effect, and AA was higher than AG and AS in antioxidant effects. The cytotoxicity was confirmed to be higher in AS than AG and AA at a concentration of 1,600 μg/ml using the MTS assay in HaCaT cells. We analyzed the effects of AG, AS, and AA on mRNA expression levels of various tight-junction related genes in HaCaT cells. We found that no obvious changes in expression of Claudin 1, 3, 4, 6, 7, 8, Occludin, JAM-A, ZO-1, ZO-2, and tricellulin by treatment of all species, suggesting that there is less possibility of side effects and skin moisturizing effects due to changes in tight-junction gene expression. Our results suggest that AG, AS, and AA are thought to be effective in reducing the oxidative stress of the skin and preventing the aging of the skin.
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KEYWORD
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Angelica gigas Nakai, Angelica sinensis (Oliv.) Diels, Angelica acutiloba Kitagawa, Anti-oxidant, Tight-junction
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